Rat
* National Institute of Infectious Diseases.
Outbred

Slc:SD
Source | Charles River Laboratories,Inc.(U.S.A)(1968) |
Coat color | Albino |
- Gentle, Good growth, High fertility, Large
- Use for studies: Biomedical research, Bioassays

Slc:Wistar
Source | Institute of Medical Science,University of Tokyo(1968) |
Coat color | Albino |
- Gentle, Good growth, High fertility, Comparatively small
- Use for studies: Biomedical research, Bioassays

Slc:Wistar/ST
Source | Institute of Medical Science,University of Tokyo(1974) |
Coat color | Albino |
- Gentle, Good growth, High fertility, Large
- Use for studies: Biomedical research, Bioassays

Iar:Long-Evans
Source | Tohoku university School of Medicine(1994 or 1996) |
Coat color | Hooded |
- Use for studies: Ophthalmology, Behavior

Hos:Donryu
Source | Japanese Foundation For Cancer Reserch(1973) |
Coat color | Albino |
- Gentle, Good growth, High fertility, Large
- High susceptibility to Yoshida sarcoma
- Use for studies: Experimental oncology
Inbred

F344/NSlc
Source | Institute of Medical Science,University of Tokyo(1980) |
Coat color | Albino |
- Gentle, Good growth, High fertility, Small
- Use for studies: Pharmacology, Long-term carcinogenicity

Arthritis
DA/Slc
Source | Kumamoto University School of medicine(1983) This strain was produced by hysterectomy and fostering(parent:SD[GN]) in 1984 |
Coat color | Dark Agouti |
- Use for studies: Adjuvant-induced arthritis, Collage-induced arthritis (CIA), Experimental allergic encephalomyelitis, Transplantation immunity, Diarrhea by the side effect of CTP -11 (irinotecan)

Arthritis
LEW/SsNSlc
Source | National Cancer Institute of Health,USA(1994) |
Coat color | c,a,h(Albino) |
- Type II collagen arthritis (Drug-induced), Autoimmunization-related cardiomyopathy

BN/SsNSlc
Source | National Cancer Institute of Health,USA(1994) |
Coat color | a,b,h(Brown) |
- Use for studies: Transplantation immunity, Allergy

WKAH/HkmSlc
Source | Hokkaido University School of Medicine(1982) |
Coat color | Albino |
- medium-sized, Nervous
- Use for studies: Transplantation immunity

ACI/NSlc
Source | U.S National Instute of Infectious Diseases(1992) |
Coat color | A、B、h1 (Brownish-grey、There is a facula of the shape of irregularity on the chest and the abdomen.) |
- Use for studies: Cancerogenesis

OM/NSlc
Source | Instiute of Medical Science,University of Tokyo. (1985) |
- Male: Glomerulus disorder with the proteinuria developed from young, Chronic renal failure by progress

FH/HamSlc
Source | The animal which shows the bleeding tendency is found in the colony which had been mating and maintained at Michigan University. In 1972, it was reported that the platelet function was abnormal.Coat Color:Hooded(fawn) Pink eyes |
- Thrombocytic serotonin releasing capacity abnormality, Decrease of quantity of blood serotonin, Prolongation of hemostasis time
- Use for studies: Renal failure with aging, Hypertension
Disease Models

Diabetes
KDP/Slc
Source | Donated to Tokyo Medical College from Otsuka Pharmaceutical Co., Ltd. as LETL rats(Patent No.2976230)(1984) Tokyo Medical College(2004) |
Coat color | Hooded |
- Type I diabetes mellitus, Autoimmune disease

Diabetes
GK/Slc
Source | Tohoku University School of Medicine(1999) |
Coat color | Albino |
- Use for studies: Type II diabetes mellitus (Elevation of blood glucose level; minor), Non-insulin-dependent Diabetes Mellitus (NIDDM)

Diabetes
WBN/KobSlc
Source | Institute of Medical Science, University of Tokyo(1978) |
Coat color | Albino |
- Male only: Hyperglycemia, Glycosuria, Cataract, Chronic pancreatitis

Diabetes・Obesity
WBN/KobSlc -Leprfa
Source | Institute of Medical Science,University of Tokyo(1978) |
Gene | Leprfa |
Coat color | Albino |
- Obesity
- Male only: Hyperglycemia, Glycosuria, Cataract, Chronic pancreatitis

Diabetes・Obesity
SHR/NDmcr -cp/cp
Source | Breeding and supply entrusted by the joint Disease Model Cooperative Research Association.(2000) |
Gene | Leprcp |
Coat color | Albino |
- Obesity, Glycosuria, Hypertension, Nephritis

Diabetes・Obesity
DahlS.Z -Leprfa/Slc
Source | Hamamatsu University School of Medicine |
Gene | Leprfa |
Coat color | Albino |
- Obesity, Glycosuria, Hypertension, Aneurysm

Diabetes・Obesity
SHRSP/IDmcr -fa/fa
Source | Breeding and supply entrusted by the joint Disease Model Cooperative Research Association.(2005) |
Gene | Leprfa |
Coat color | Albino |
- Obesity, Hypertension, Cerebrovascular disorder

Obesity
Slc:Zucker -fa/fa
Source | Tokyo University School of Medicine(1996) |
Gene | Leprfa |
Coat color | Hooded |
- Obesity, Ectopic calcification

Diabetes・Obesity
Hos:ZFDM -Leprfa
Source | Hoshino Laboratory Animals, Inc.(2008) |
Gene | Leprfa |
Coat color | Hooded |
- Use for studies: Obesity, Hyperlipidemia, Non-insulin-dependent diabetes mellitus, Diabetic nephropathy

Hypertension
SHR/Izm
(Hypertensive diseases)
SHRSP/Izm(Stroke)
WKY/Izm(Control to SHR/lzm)
Source | Breeding and supply entrusted by the Joint Research Association for Disease Models such as SHR (2000) |
Coat color | Albino |
- Hypertension (SHR/Izm)
- Cerebrovascular disorder (SHRSP/Izm)

Hypertension
DIS/EisSlc (Dahl-lwai S)
(Salt-sensitive rat)
DIR/EisSlc (Dahl-lwai R)
(Salt-resistant rat)
Source | These rats are bred and produced at Esai co., Ltd., and provided by SLC.(2004) |
Coat color | Albino |
- High salt sensitive hypertension (DIS/EisSlc)
- Salt resistance (DIR/EisSlc)
- Heart failure and blood pressure-related study: Use of the exclusive feed

NASH
SHRSP5/Dmcr
Source | Distribution of breeding production by entrusted the joint Disease Model Cooperative Research Association(DMCRA). |
- Fatty deposition of intestinal membrane artery: High fat diet (HFC) (Funabashi Farm Co.,Ltd.)
- Severe fibrosis of liver by fatty deposition

Colon caner-prone
F344/NSlc -Apcmlkyo
KAD(Kyoto Apc delta)
Source | Institute of Laboratory Animals, Kyoto University |
Coat color | Albino |
- This strain was produced by ENU mutagenesis using F344/NSlc and had nonsense mutation (S2523X) in the Apc gene which is a cause gene of family type colorectal cancer.
- Remarkable colorectal cancer susceptibility : azoxy methane (AOM) + dextran sulfate (DSS)

Hyperbilirubinuria
EHBR/EisSlc
(Hyper-brilirubinuric rat)
Source | Breeding and sales entrusted by Eisai Co.,Ltd.(2004) |
Coat color | Albino |
- Use for studies: Bilirubin metabolism (human constitutional jaundice model), Toxic evaluation of the organic anionic drug

Dwarfism
SDR
(Dwarf rat)
Source | Hoechst Marion Roussel Inc.Japan(1996) |
Coat color | Albino |
- Deficiency of the somatotrope in anterior pituitary glands, Dwarfish

Mast cell deficiency
Slc:WsRC -Ws/Ws
Source | Laboratory of experimental Animals,Yagi Memorial Park(1993) |
Gene | KitWs |
Coat color | White color and Black eyes |
- Anemia, Mast cells deficiency
- Use for studies: Enterokinesis function

Hairlessness
HWY/Slc
(Hairless rat)
Source | Laboratory of Experimental Animals,Yagi Memorial Park(1993) |
Coat color | Hairless rat(Albino) |
- Use for studies: Clinic and fundamental researches of the skin, Percutaneous absorption, UV radiation, Pressure sore
- J Anat. 1997 Jul; 191: 99–106. Hair follicles of young Wistar strain hairless rats: a histological study
Transgenic(GFP)

SD-Tg
(CAG-EGFP)
(Green rat)
Source | Genome Information Research Center,Osaka University(2002) |
- Most tissue cells express EGFP by CAG promoter and express green fluorescence (Photo ※).
The customers using the above animals with modified genes are kindly requested to comply with related laws.
A GFP license is required for commercial organizations to utilize the above animals.
Inbred

F344/NSlc[GF]
Source | Institute of Medical Science,University of Tokyo(1980) |
Coat color | Albino |
- small in body size
- Rapid growth rate
- Low level of aggressiveness
- Easy to handle because of their gentleness
- Used for pharmacology, efficacy, and long-term carcinogenicity tests